Cellular reprogramming

Upon completion of the course, the doctoral student will be familiar with mechanisms of nuclear reprogramming and how reprogramming techniques can be utilized in various research areas. Emphasis will be put on providing the student with knowledge to critically read and evaluate research work in the reprogramming field, as well as on how appropriate reprogramming methods and procedures can be applied in various research projects.

The course is composed of lectures that address different aspects of cellular reprogramming, i.e. how cellular identity can be changed, covering both basic scientific mechanisms as well as experimental procedures of cellular reprogramming. The primary focus will be on the reprogramming of fully differentiated cells to induced pluripotent stem (iPS) cells, but direct reprogramming from one differentiated state to another will be discussed as well. Controlled differentiation of pluripotent cells to specific fates and the use of cellular reprogramming in disease modeling will be discussed, and course participants will also be provided with a practical demonstration of the reprogramming procedure.

The course directors are Anna Falk, email Anna.Falk@ki.se and Emil Hansson.

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