MLL transcripts

The MLL gene spans approximately 89 kb of DNA and contains 36 exons exons. Analysis of MLL in the UCSC genome browser indicates that, although several mRNA and ESTs have been identified, there is only one human Refseq sequence for MLL (NM_005933.2), suggesting that there is no alternative splice variants. However, UCSC Gene Predictions include other possible variants with less exons (uc001psz.1,uc001ptd.1 and uc001pte.1). The mouse and rat Refseqs are similar to the human, except for exon 27, which appears to be alternatively spliced. The Danio rario Refseq indicates the absence of certain exons.

Analysis of MLL in the ENSEMBL genome browser also reveals another possible variant, with 20 exons (Q9HB80_HUMAN).

These possible transcript variants would translate into proteins containing only certain domains. For instance, Q9hb80 would only contain the DNA binding domain and the zinc binding domain, as assessed in Uniprot.