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The Pfam-database (http://pfam.sanger.ac.uk/) holds information about the protein-domain structur of Notch1, which can be seen as an assembled overview below:

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To discribe the above shown protein-domains, particular characterisations are listed below:

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NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species. The role of the NOD and NODP domains remain to be elucidated.

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The tertiary structure of Notch1 assembled of the mentioned domains, binding to the (DNA-binding) CSL-protein :

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References:

http://genome.uscs.edu/

http://pfam.sanger.ac.uk/

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-- SebastianHildebrand - 19 May 2008