Complete list of Publications

PUBLICATIONS

List of all DBRM publications sorted in year/alphabetical order with links.

2010

ORIGINAL ARTICLES

Andersson F, Löw P, Brodin L. Selective perturbation of the BAR domain of endophilin impairs synaptic vesicle endocytosis. Synapse (2010) 64:556-560.

Arner E, Westermark PO, Spalding KL, Britton T, Rydén M, Frisén J, Bernard S, Arner P. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes (2010) 59:105-109.

Hajji N, Wallenborg K, Vlachos P, Füllgrabe J, Hermanson O, Joseph B. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. Oncogene (2010) Feb 1. [Epub ahead of print]

Jiao W, Shupliakov A, Shupliakov O. A semi-correlative technique for the subcellular localization of proteins in Drosophila synapses. J Neurosci Methods (2010) 185:273-279.

Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U. Evidence for dimeric BACE-mediated APP processing. Biochem Biophys Res Commun (2010) Jan 25. [Epub ahead of print]

Jäderstad J, Jäderstad LM, Li J, Chintawar S, Salto C, Pandolfo M, Ourednik V, Teng YD, Sidman RL, Arenas E, Snyder EY, Herlenius E. Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host. Proc Natl Acad Sci U S A (2010) Feb 10. [Epub ahead of print]

Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T. Vang-like protein 2 and Rac1 interact to regulate adherens junctions. J Cell Sci (2010) 123:472-483.

Main H, Lee KL, Yang H, Haapa-Paananen S, Edgren H, Jin S, Sahlgren C, Kallioniemi O, Poellinger L, Lim B, Lendahl U. Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells. Exp Cell Res (2009) Dec 23. [Epub ahead of print]

Malmersjö S, Liste I, Dyachok O, Tengholm A, Arenas E, Uhlén P. Ca2+ and cAMP signaling in human embryonic stem cell-derived dopamine neurons. Stem Cells Dev (2009) Dec 31. [Epub ahead of print]

Marklund U, Hansson EM, Sundström E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J. Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development (2010) 137:437-445.

Morrison JI, Borg P, Simon A. Plasticity and recovery of skeletal muscle satellite cells during limb regeneration. FASEB J (2009) Nov 6. [Epub ahead of print]

Ogundare M, Theofilopoulos S, Lockhart A, Hall LJ, Arenas E, Sjövall J, Brenton AG, Wang Y, Griffiths WJ. Cerebrospinal fluid steroidomics: Are bioactive bile acids present in brain? J Biol Chem (2009) Dec 7. [Epub ahead of print]

Seidel S, Garvalov BK, Wirta V, von Stechow L, Sch√§nzer A, Meletis K, Wolter M, Sommerlad D, Henze AT, Nist√©r M, Reifenberger G, Lundeberg J, Fris√©n J, Acker T. A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2{alpha}. Brain (2010) 133:983-995.

Sousa KM, Villaescusa JC, Cajanek L, Ondr JK, Castelo-Branco G, Hofstra W, Bryja V, Palmberg C, Bergman T, Wainwright B, Lang RA, Arenas E. WNT2 regulates progenitor proliferation in the developing ventral midbrain. J Biol Chem (2009) Dec 17. [Epub ahead of print]

Pechstein A, Bacetic J, Vahedi-Faridi A, Gromova K, Sundborger A, Tomlin N, Krainer G, Vorontsova O, Schäfer JG, Owe SG, Cousin MA, Saenger W, Shupliakov O, Haucke V. Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. Proc Natl Acad Sci U S A (2010) 107:4206-4211. Epub 2010 Feb 16.

Rojas P, Joodmardi E, Perlmann T, Ögren SO. Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice. J Neurosci Res (2010) Feb 19. [Epub ahead of print]

Staaf S, Franck MC, Marmigère F, Mattsson JP, Ernfors P. Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns (2010) 10:65-74.

REVIEW ARTICLES, PREVIEWS AND BOOK CHAPTERS

Ernfors P. Cellular origin and developmental mechanisms during the formation of skin melanocytes. Exp Cell Res (2010) Mar 5. [Epub ahead of print]

Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci (2010) 11:77-86.

Pechstein A, Shupliakov O, Haucke V. Intersectin 1: a versatile actor in the synaptic vesicle cycle. Biochem Soc Trans (2010) 38:181-186.

Shupliakov O, Brodin L. Recent insights into the building and cycling of synaptic vesicles. Exp Cell Res (2010) Mar 5. [Epub ahead of print]

Simi A, Ibáñez CF. Assembly and activation of neurotrophic factor receptor complexes. Dev Neurobiol (2010) 70:323-331. [Epub ahead of print]

Villaescusa JC, Arenas E. Transplantable midbrain dopamine neurons: A moving target. Exp Neurol (2010) Jan 6. [Epub ahead of print]

2009

ORIGINAL ARTICLES

Adameyko I, Lallemend F, Aquino JB, Pereira JA, Topilko P, Müller T, Fritz N, Beljajeva A, Mochii M, Liste I, Usoskin D, Suter U, Birchmeier C, Ernfors, P. Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell (2009) 139:366-379.

Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, Uhlén P, Estrada M. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol (2009) 202:299-307.

Andersson ER, Bryjova L, Biris K, Yamaguchi TP, Arenas E, Bryja V. Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev Dyn (2009) [Epub ahead of print]

Andersson T, Södersten E, Duckworth JK, Cascante A, Fritz N, Sacchetti P, Cervenka I, Bryja V, Hermanson O. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. J Biol Chem (2009) 284:3672-3681.

Aquino JB, Lallemend F, Marmigère F, Adameyko II, Golemis EA, Ernfors P. The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics. Neuroscience (2009) 162:1106-1119.

Ashique AM, Choe Y, Karlén M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS. The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal (2009) 2:ra70.

Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for cardiomyocyte renewal in humans. Science (2009) 324:98-102.

Bryja V, Andersson ER, Schambony A, Esner M, Bryjová L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E. The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell (2009) 20:924-936.

Cajánek L, Ribeiro D, Liste I, Parish CL, Bryja V, Arenas E. Wnt/beta-Catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells (2009) [Epub ahead of print]

Canty AJ, Dietze J, Harvey M, Enomoto H, Milbrandt J, Ibáñez CF. Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. J Neurosci (2009) 29:10695-10705.

Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabé-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisén J. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci (2009) 12:259-267.

Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E. Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Dev Dyn (2009) [Epub ahead of print]

Desfrere L, Karlsson M, Hiyoshi H, Malmersjö S, Nanou E, Estrada M, Miyakawa A, Lagercrantz H, El Manira A, Lal M, Uhlén P. Na,K-ATPase signal transduction triggers CREB activation and dendritic growth. Proc Natl Acad Sci USA (2009) 106:2212-2217.

Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, Alekseenko Z, Marklund U, Kjellander S, Volakakis N, Hovatta O, El Manira A, Björklund A, Perlmann T, Ericson J. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci USA (2009) 106:7613-7618.

Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisén J. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell (2009) 139:679-692.

Joseph B, Andersson ER, Vlachos P, Södersten E, Liu L, Teixeira AI, Hermanson O. p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells. Cell Death Differ (2009) 16:1256-1265.

Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Björklund A, Ichinose H, Perlmann T. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci (2009) 29:15923-15932.

Kunke D, Bryja V, Mygland L, Arenas E, Krauss S. Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs. Biochem Biophys Res Commun. 2009 Sep 4;386(4):628-633.

Lindström S, Eriksson M, Vazin T, Sandberg J, Lundeberg J, Frisén J, Andersson-Svahn H. High-density microwell chip for culture and analysis of stem cells. PLoS One (2009) 4:e6997.

Nyman U, Vlachos P, Cascante A, Hermanson O, Zhivotovsky B, Joseph B. PKC-Dependent phosphorylation regulates the cell cycle inhibitory function of the p73 carboxy-terminus transactivation domain. Mol Cell Biol (2009) 29:1814-1825.

Owe SG, Jensen V, Evergren E, Ruiz A, Shupliakov O, Kullmann DM, Storm-Mathisen J, Walaas SI, Hvalby O, Bergersen LH. Synapsin- and actin-dependent frequency enhancement in mouse hippocampal mossy fiber synapses. Cereb Cortex (2009) 19:511-523.

Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (2009) 136:2545-2555.

Rauen T, Raffetseder U, Frye BC, Djudjaj S, Mühlenberg PJ, Eitner F, Lendahl U, Bernhagen J, Dooley S, Mertens PR. YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. J Biol Chem (2009) 284:26928-26940.

Rawal N, Corti O, Sacchetti P, Ardilla-Osorio H, Sehat B, Brice A, Arenas E. Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem Biophys Res Commun (2009) 388:473-478.

Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E. Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell (2009) 5:409-419.

Staaf S, Maxvall I, Lind U, Husmark J, Mattsson JP, Ernfors P, Pierrou S. Down regulation of TRPC1 by shRNA reduces mechanosensitivity in mouse dorsal root ganglion neurons in vitro. Neurosci Lett (2009) 457:3-7.

Staaf S, Oerther S, Lucas G, Mattsson JP, Ernfors P. Differential regulation of TRP channels in a rat model of neuropathic pain. Pain (2009) 144:187-199.

Teixeira AI, Ilkhanizadeh S, Wigenius JA, Duckworth JK, Inganäs O, Hermanson O. The promotion of neuronal maturation on soft substrates. Biomaterials (2009) 30:4567-4572.

Vilar M, Charalampopoulos I, Kenchappa RS, Reversi A, Klos-Applequist JM, Karaca E, Simi A, Spuch C, Choi S, Friedman WJ, Ericson J, Schiavo G, Carter BD, Ibáñez CF. Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. J Cell Sci (2009) 122:3351-3357.

Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ibáñez CF. Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 62:72-83.

Volakakis N, Joodmardi E, Perlmann T. NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5. Biochem Biophys Res Commun (2009) 390:1186-1191.

Wallenborg K, Vlachos P, Eriksson S, Huijbregts L, Arnér ES, Joseph B, Hermanson O. Red wine triggers cell death and thioredoxin reductase inhibition:effects beyond resveratrol and SIRT1. Exp Cell Res (2009) 315:1360-1371.

Wang Y, Sousa KM, Bodin K, Theofilopoulos S, Sacchetti P, Hornshaw M, Woffendin G, Karu K, Sjövall J, Arenas E, Griffiths WJ. Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Mol Biosyst (2009) 5:529-541.

Yang DH, Yoon JY, Lee SH, Bryja V, Andersson ER, Arenas E, Kwon YG, Choi KY. Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/{beta}-catenin and protein kinase C{alpha}. Circ Res (2008) 104:372-379.

Zhao J, Liu T, Jin SB, Tomilin N, Castro J, Shupliakov O, Lendahl U, Nistér M. The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation. J Cell Sci (2009) 122:2252-2262.

Zheng Y, Vertuani S, Nyström S, Audebert S, Meijer I, Tegnebratt T, Borg JP, Uhlén P, Majumdar A, Holmgren L. Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Circ Res (2009) 105:260-270.

Zhu SW, Codita A, Bogdanovic N, Hjerling-Leffler J, Ernfors P, Winblad B, Dickins DW, Mohammed AH. Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice. Behav Brain Res (2009) 197:339-346.

REVIEW ARTICLES, PREVIEWS AND BOOK CHAPTERS

Andersson ER, Lendahl U. Regenerative medicine: a 2009 overview. J Intern Med (2009) 266:303-310.

Hedlund E, Perlmann T. Neuronal cell replacement in Parkinson's disease. J Intern Med (2009) 266:358-371.

Lendahl U, Lee KL, Yang H, Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet (2009) 10:821-32.

Shupliakov O. The synaptic vesicle cluster: a source of endocytic proteins during neurotransmitter release. Neuroscience (2009) 158:204-210.

Simon A, Berg D, Kirkham M. Not lost in translation Sensing the loss and filling the gap during regeneration. Semin Cell Dev Biol (2009) 20:691-696.

2008

ORIGINAL ARTICLES (bold indicates articles in publications with high impact factor, thus not necessarily the best publications)

Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE (2008) 3:e3517.

Andersson F, Jakobsson J, Löw P, Shupliakov O, Brodin L. Perturbation of syndapin/PACSIN impairs synaptic vesicle recycling evoked by intense stimulation. J Neurosci (2008) 28:3925-3933.

Andersson O, Korach-Andre M, Reissmann E, Ibáñez CF, Bertolino P. Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci USA (2008) 105:7252-7256.

Andäng M, Hjerling-Leffler J, Moliner A, Lundgren TK, Castelo-Branco G, Nanou E, Pozas E, Bryja V, Halliez S, Nishimaru H, Wilbertz J, Arenas E, Koltzenburg M, Charnay P, Manira AE, Ibáñez CF, Ernfors P. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature (2008) 451:460-464.

Andäng M, Moliner A, Doege CA, Ibáñez CF, Ernfors P. Optimized mouse ES cell culture system by suspension growth in a fully defined medium. Nat Protocols (2008) 3:1013-1017.

Aquino JB, Marmigère F, Lallemend F, Lundgren TK, Villar MJ, Wegner M, Ernfors P. Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues. Gene Expr Patterns (2008) 8:217-226.

Barnabé-Heider F, Meletis K, Eriksson M, Bergmann O, Sabelström H, Harvey MA, Mikkers H, Frisén J. Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation. Nat Methods (2008) 5:189-196.

Baudet C, Pozas E, Adameyko I, Andersson E, Ericson J, Ernfors P. Retrograde signaling onto Ret during motor nerve terminal maturation. J Neurosci (2008) 28:963-975.

Bertolino P, Holmberg R, Reissmann E, Andersson O, Berggren PO, Ibáñez CF. Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci USA (2008) 105:7246-7251.

Bonilla S, Hall AC, Pinto L, Attardo A, Götz M, Huttner WB, Arenas E. Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors. Glia (2008) 56:809-820.

Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G. beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep (2008) 9:1244-1250.

Duinsbergen D, Eriksson M, 't Hoen PA, Frisén J, Mikkers H. Induced pluripotency with endogenous and inducible genes. Exp Cell Res (2008) 314:3255-3263.

Edman LC, Mira H, Arenas E. The beta-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons. Exp Cell Res (2008) 314:2123-2130.

Edman LC, Mira H, Erices A, Malmersjö S, Andersson E, Uhlén P, Arenas E. {alpha} Chemokines regulate proliferation, neurogenesis and dopaminergic differentiation of ventral midbrain precursors and neurospheres. Stem Cells (2008) 26:1891-1900.

Jakobsson J, Gad H, Andersson F, Löw P, Shupliakov O, Brodin L. Role of epsin 1 in synaptic vesicle endocytosis. Proc Natl Acad Sci USA (2008) 105:6445-6450.

Jung GA, Yoon JY, Moon BS, Yang DH, Kim HY, Lee SH, Bryja V, Arenas E, Choi KY. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway. BMC Cell Biol (2008) 9:66.

Hajji N, Wallenborg K, Vlachos P, Nyman U, Hermanson O, Joseph B. Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. Oncogene (2008) 27:3134-3144.

Holmberg J, Hansson E, Malewicz M, Sandberg M, Perlmann T, Lendahl U, Muhr J. SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation. Development (2008) 135:1843-1851.

Jin S, Hansson EM, Tikka S, Lanner F, Sahlgren C, Farnebo F, Baumann M, Kalimo H, Lendahl U. Notch signaling regulates platelet-derived growth factor receptor-{beta} expression in vascular smooth muscle cells. Circ Res (2008) 102:1483-1491.

Kiss I, Rühl R, Szegezdi E, Fritzsche B, Tóth B, Pongrácz J, Perlmann T, Fésüs L, Szondy Z. Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development. Eur J Immunol (2008) 38:147-155.

Lammi J, Perlmann T, Aarnisalo P. Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers. Arch Biochem Biophys (2008) 472:105-114.

Lundgren TK, Luebke M, Stenqvist A, Ernfors P. Differential membrane compartmentalization of Ret by PTB-adaptor engagement. FEBS J (2008) 275:2055-2066.

Lundgren TK, Stenqvist A, Scott RP, Pawson T, Ernfors P. Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors. J Cell Biochem (2008) 104:879-894.

Moliner A, Enfors P, Ibáñez CF, Andäng M. Mouse embryonic stem cell-derived spheres with distinct neurogenic potentials. Stem Cells Dev (2008) 17:233-244.

Meletis K, Barnabé-Heider F, Carlén M, Evergren E, Tomilin N, Shupliakov O, Frisén J. Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol (2008) 6:e182.

Norberg E, Gogvadze V, Ott M, Horn M, Uhlén P, Orrenius S, Zhivotovsky B. An increase in intracellular Ca(2+) is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ (2008) 15:1857-1864.

Parish CL, Castelo-Branco G, Rawal N, Tonnesen J, Sorensen AT, Salto C, Kokaia M, Lindvall O, Arenas E. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J Clin Invest (2008) 118:149-160.

Passante L, Gaspard N, Degraeve M, Frisén J, Kullander K, De Maertelaer V, Vanderhaeghen P. Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum. Development (2008) 135:3281-3290.

Raju CS, Göritz C, Nord Y, Hermanson O, López-Iglesias C, Visa N, Castelo-Branco G, Percipalle P. In cultured oligodendrocytes the A/B-type hnRNP CBF-a accompanies MBP mRNA bound to mRNA trafficking sequences. Mol Biol Cell (2008) 19:3008-3019.

Rizzo P, Miao H, D'Souza G, Osipo C, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res (2008) 68:5226-5235.

Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A (2008) 105:6392-6397.

Saltó C, Saindon E, Bolin M, Kanciurzewska A, Fahlman M, Jager EW, Tengvall P, Arenas E, Berggren M. Control of neural stem cell adhesion and density by an electronic polymer surface switch. Langmuir (2008) 24:14133-14138.

Sjöstrand D, Ibáñez CF. Insights into GFR{alpha}1 regulation of neural cell adhesion molecule (NCAM) function from structure-function analysis of the NCAM/GFR{alpha}1 receptor complex. J Biol Chem (2008) 283:13792-13798.

Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L. Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. Oncogene (2008) 27:5833-5844.

Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Näslund E, Britton T, Concha H, Hassan M, Rydén M, Frisén J, Arner P. Dynamics of fat cell turnover in humans. Nature (2008) 453:783-787.

Stenqvist A, Lundgren TK, Smith MJ, Hermanson O, Castelo-Branco G, Pawson T, Ernfors P. Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok. Neurosci Lett (2008) 435:11-16.

Tamm C, Duckworth JK, Hermanson O, Ceccatelli S. Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling. Neuroreport (2008) 19:339-343.

Wallis K, Sjögren M, van Hogerlinden M, Silberberg G, Fisahn A, Nordström K, Larsson L, Westerblad H, Morreale de Escobar G, Shupliakov O, Vennström B. Locomotor deficiencies and aberrant development of subtype-specific GABAergic interneurons caused by an unliganded thyroid hormone receptor alpha1. J Neurosci (2008) 28:1904-1915.

Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisén J, Sehara-Fujisawa A. Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS ONE (2008) 3:e3322.

Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A. (2008) 105:3368-3373.

Åberg E, Perlmann T, Olson L, Brené S. Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus. Hippocampus (2008) 18:785-792.

REVIEW ARTICLES, PREVIEWS AND BOOK CHAPTERS

Andäng M, Lendahl U. Ion fluxes and neurotransmitters signaling in neural development. Curr Opin Neurobiol (2008) 18:232-236.

Arenas E. Foxa2: the rise and fall of dopamine neurons. Cell Stem Cell (2008) 2:110-112.

Galliot B, Tanaka E, Simon A. Regeneration and tissue repair: themes and variations. Cell Mol Life Sci (2008) 65:1-7.

Barnabé-Heider F, Frisén J. Stem cells for spinal cord repair. Cell Stem Cell (2008) 3:16-24.

Hermanson O. Stem cells have different needs for REST. PLoS Biol (2008) 6:e271.

Ibáñez CF. Catecholaminergic neuron survival: getting hooked on GDNF. Nat Neurosci (2008) 11:735-736.

Ibáñez CF, Häusser M. Signaling mechanisms. Curr Opin Neurobiol (2008) 18:229-231.

Lendahl U. [Dedifferentiation of specialized cells. New way open for cell therapy and regenerative medicine] Läkartidningen (2008) 105:1492-1494.

Poellinger L, Lendahl U. Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr Opin Genet Dev (2008) 18:449-454.

2007

ORIGINAL ARTICLES

Andersson O, Bertolino P, Ibáñez CF. Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol (2007) 311:500-511.

Bryja V, Gradl D, Schambony A, Arenas E, Schulte G. {beta}-Arrestin is a necessary component of Wnt/{beta}-catenin signaling in vitro and in vivo. Proc Natl Acad Sci U S A (2007) 104:6690-6695.

Bryja V, Schulte G, Arenas E. Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cell Signal (2007) 19:610-616.

Bryja V, Schulte G, Rawal N, Grahn A, Arenas E. Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J Cell Sci (2007) 120:586-595.

Curtis MA, Kam M, Nannmark U, Anderson MF, Axell MZ, Wikkelso C, Holtas S, van Roon-Mom WM, Björk-Eriksson T, Nordborg C, Frisén J, Dragunow M, Faull RL, Eriksson PS. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science (2007) 315:1243-1249.

Dohda T, Maljukova A, Liu L, Heyman M, Grander D, Brodin D, Sangfelt O, Lendahl U. Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. Exp Cell Res (2007) 313:3141-3152.

Elg S, Marmigère F, Mattsson JP, Ernfors P. Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion. J Comp Neurol (2007) 503:35-46.

Evergren E, Gad H, Walther K, Sundborger A, Tomilin N, Shupliakov O. Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse. J Neurosci (2007) 27:379-390.

Falk A, Karlsson TE, Kurdija S, Frisén J, Zupicich J. High-throughput identification of genes promoting neuron formation and lineage choice in mouse embryonic stem cells. Stem Cells (2007) 25:1539-1545.

Hjerling-Leffler J, Alqatari M, Ernfors P, Koltzenburg M. Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. J Neurosci (2007) 27:2435-2443.

Ilkhanizadeh S, Teixeira AI, Hermanson O. Inkjet printing of macromolecules on hydrogels to steer neural stem cell differentiation. Biomaterials (2007) 28:3936-3943.

Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK, Hermanson O, Rosenfeld MG. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature (2007) 450:415-419.

Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ. Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol (2007) 178:309-322.

Ledda F, Paratcha G, Sandoval-Guzmán T, Ibáñez CF. GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat Neurosci (2007) 10:293-300.

Lööf S, Straube WL, Drechsel D, Tanaka EM, Simon A. Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor. Cell Cycle (2007) 6:1096-1101.

Malyukova A, Dohda T, von der Lehr N, Akhondi S, Corcoran M, Heyman M, Spruck C, Grander D, Lendahl U, Sangfelt O. The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res (2007) 67:5611-5616.

Montelius A, Marmigère F, Baudet C, Aquino JB, Enerbäck S, Ernfors P. Emergence of the sensory nervous system as defined by Foxs1 expression. Differentiation (2007) 75:404-417.

Morrison JI, Lööf S, He P, Aleström P, Collas P, Simon A. Targeted gene delivery to differentiated skeletal muscle: a tool to study dedifferentiation. Dev Dyn (2007) 236:481-488.

Parish CL, Beljajeva A, Arenas E, Simon A. Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model. Development (2007) 134:2881-2887.

Pineda JR, Rubio N, Åkerud P, Urban N, Badimon L, Arenas E, Alberch J, Blanco J, Canals JM. Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells. Gene Ther (2007) 14:118-128.

Rawal N, Parish C, Castelo-Branco G, Arenas E. Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats. Cell Death Differ (2007) 14:381-383.

Rojas P, Joodmardi E, Hong Y, Perlmann T, Ögren SO. Adult mice with reduced Nurr1 expression: an animal model for schizophrenia. Mol Psychiatry (2007) 12:756-766.

Sjöstrand D, Carlsson J, Paratcha G, Persson B, Ibáñez CF. Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion. J Biol Chem (2007) 282:12734-12740.

Slezak M, Göritz C, Niemiec A, Frisén J, Chambon P, Metzger D, Pfrieger FW. Transgenic mice for conditional gene manipulation in astroglial cells. Glia (2007) 55:1565-1576.

Sousa KM, Mira H, Hall AC, Jansson-Sjöstrand L, Kusakabe M, Arenas E. Microarray analyses support a role for Nurr1 in resistance to oxidative stress and neuronal differentiation in neural stem cells. Stem Cells (2007) 25:511-519.

REVIEW ARTICLES, PREVIEWS AND BOOK CHAPTERS

Evergren E, Benfenati F, Shupliakov O. The synapsin cycle: A view from the synaptic endocytic zone. J Neurosci Res (2007) 85:2648-2656.

Ibáñez CF. Message in a bottle: long-range retrograde signaling in the nervous system. Trends Cell Biol (2007) 17:519-528.

Ibáñez CF, Ernfors P. Hierarchical control of sensory neuron development by neurotrophic factors. Neuron (2007) 54:673-675.

Marmigère F, Ernfors P. Specification and connectivity of neuronal subtypes in the sensory lineage. Nat Rev Neurosci (2007) 8:114-127.

Omary MB, Herrmann H, Lendahl U. Special issue: Intermediate filaments. Exp Cell Res (2007) 313:1979-1980.

Parish CL, Arenas E. Stem-cell-based strategies for the treatment of Parkinson's disease. Neurodegener Dis (2007) 4:339-347.

Ruas JL, Lendahl U, Poellinger L. Modulation of vascular gene expression by hypoxia. Curr Opin Lipidol (2007) 18:508-514.

Simon A, Frisén J. From stem cell to progenitor and back again. Cell (2007) 128:825-826.

Teixeira AI, Duckworth JK, Hermanson O. Getting the right stuff: controlling neural stem cell state and fate in vivo and in vitro with biomaterials. Cell Res (2007) 17:56-61.

2006

ORIGINAL ARTICLES

Alanentalo T, Chatonnet F, Karlén M, Sulniute R, Ericson J, Andersson E, Ahlgren U. Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr Patterns (2006) 6:162-170.

Alcantara S, Pozas E, Ibáñez CF, Soriano E. BDNF-modulated Spatial Organization of Cajal-Retzius and GABAergic Neurons in the Marginal Zone Plays a Role in the Development of Cortical Organization. Cereb Cortex (2006) 16:487-499.

Andersson E, Tryggvason U, Deng Q, Friling S, Alekseenko Z, Robert B, Perlmann T, Ericson J. Identification of intrinsic determinants of midbrain dopamine neurons. Cell (2006) 124:393-405.

Andersson O, Reissmann E, Ibáñez CF. Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep (2006) 7:831-837.

Andersson O, Reissmann E, Jörnvall H, Ibáñez CF. Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol (2006) 293:370-381.

Aquino JB, Hjerling-Leffler J, Koltzenburg M, Edlund T, Villar MJ, Ernfors P. In vitro and in vivo differentiation of boundary cap neural crest stem cells into mature Schwann cells. Exp Neurol (2006) 198:438-449.

Bailey PJ, Klos JM, Andersson E, Karlén M, Källström M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J. A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res (2006) 312:3108-3119.

Bakshi A, Shimizu S, Keck CA, Cho S, LeBold DG, Morales D, Arenas E, Snyder EY, Watson DJ, McIntosh TK. Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. Eur J Neurosci (2006) 23:2119-2134.

Berghuis P, Agerman K, Dobszay MB, Minichiello L, Harkany T, Ernfors P. Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway. J Neurobiol (2006) 66:1437-1451.

Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J. The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes Dev (2006) 20:3475-3486.

Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Björk-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisén J. Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A (2006) 103:12564-12568.

Bryja V, Bonilla S, Arenas E. Derivation of mouse embryonic stem cells. Nature Protocols (2006) 1:2082-2087.

Bryja V, Bonilla S, Cajanek L, Parish CL, Schwartz CM, Luo Y, Rao MS, Arenas E. An efficient method for the derivation of mouse embryonic stem cells. Stem Cells (2006) 24:844-849.

Carlén M, Meletis K, Barnabé-Heider F, Frisén J. Genetic visualization of neurogenesis. Exp Cell Res (2006) 312:2851-2859.

Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol Cell Neurosci (2006) 31:251-262.

Chapman G, Liu L, Sahlgren C, Dahlqvist C, Lendahl U. High levels of Notch signaling down-regulate Numb and Numblike. J Cell Biol (2006) 175:535-540.

Estrada M, Uhlén P, Ehrlich BE. Ca2+ oscillations induced by testosterone enhance neurite outgrowth. J Cell Sci (2006) 119:733-743.

Evergren E, Zotova E, Brodin L, Shupliakov O. Differential efficiency of the endocytic machinery in tonic and phasic synapses. Neuroscience (2006) 141:123-131.

Goebbels S, Bormuth I, Bode U, Hermanson O, Schwab MH, Nave KA. Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice. Genesis (2006) 44:611-621.

Hansson EM, Teixeira AI, Gustafsson MV, Dohda T, Chapman G, Meletis K, Muhr J, Lendahl U. Recording notch signaling in real time. Dev Neurosci (2006) 28:118-127.

Hermanson E, Borgius L, Bergsland M, Joodmardi E, Perlmann T. Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem. J Neurochem (2006) 97:1403-1411.

Holm PC, Rodriguez FJ, Kele J, Castelo-Branco G, Kitajewski J, Arenas E. BMPs, FGF8 and Wnts regulate the differentiation of locus coeruleus noradrenergic neuronal precursors. J Neurochem (2006) 99:343-352.

Holmberg J, Genander M, Halford MM, Anneren C, Sondell M, Chumley MJ, Silvany RE, Henkemeyer M, Frisén J. EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell (2006) 125:1151-1163.

Kele J, Simplicio N, Ferri AL, Mira H, Guillemot F, Arenas E, Ang SL. Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development (2006) 133:495-505.

Kjaer S, Kurokawa K, Perrinjaquet M, Abrescia C, Ibáñez CF. Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations. Oncogene (2006) 25:7086-7095.

Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibáñez CF, McDonald NQ. Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem (2006) 44:33577-33587.

Kowalewski JM, Uhlén P, Kitano H, Brismar H. Modeling the impact of store-operated Ca(2+) entry on intracellular Ca(2+) oscillations. Math Biosci (2006) 204:232-249.

Kropotov A, Gogvadze V, Shupliakov O, Tomilin N, Serikov VB, Tomilin NV, Zhivotovsky B. Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res (2006) 312:2806-2815.

Lundgren TK, Scott RP, Smith M, Pawson T, Ernfors P. Engineering the recruitment of PTB adaptor proteins reveals distinct roles for Ret receptor-mediated cell survival. J Biol Chem (2006) 281:29886-29896.

Marmigère F, Montelius A, Wegner M, Groner Y, Reichardt LF, Ernfors P. The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons. Nat Neurosci (2006) 9:180-187.

Martin-Ibañez R, Jenstad M, Berghuis P, Edwards RH, Hioki H, Kaneko T, Mulder J, Canals JM, Ernfors P, Chaudhry FA, Harkany T. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci (2006) 23:1063-1070.

Masich S, Östberg T, Norlén L, Shupliakov O, Daneholt B. A procedure to deposit fiducial markers on vitreous cryo-sections for cellular tomography. J Struct Biol (2006) 156:461-468.

Meletis K, Wirta V, Hede SM, Nistér M, Lundeberg J, Frisén J. p53 suppresses the self-renewal of adult neural stem cells. Development (2006) 133:363-369.

Morrison JI, Lööf S, He P, Simon A. Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. J Cell Biol (2006) 172:433-440.

Nomura T, Holmberg J, Frisén J, Osumi N. Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5. Development (2006) 133:1335-1345.

Otal R, Burgaya F, Frisén J, Soriano E, Martinez A. Ephrin-A5 modulates the topographic mapping and connectivity of commissural axons in murine hippocampus. Neuroscience (2006) 141:109-121.

Paratcha G, Ibáñez CF, Ledda F. GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. Mol Cell Neurosci (2006) 31:505-514.

Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (2006) 133:89-98.

Rawal N, Castelo-Branco G, Sousa KM, Kele J, Kobayashi K, Okano H, Arenas E. Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain. Exp Cell Res (2006) 312:1626-1636.

Svärd J, Henricson KH, Persson-Lek M, Rozell B, Lauth M, Bergström Å, Ericson J, Toftgård R, Teglund S. Genetic elimination of suppressor of fused reveals an essential repressor function in the Mammalian hedgehog signaling pathway. Dev Cell (2006) 10:187-197.

Tamm C, Duckworth J, Hermanson O, Ceccatelli S. High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem (2006) 97:69-78.

Uhlén P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc Natl Acad Sci U S A (2006) 103:2160-2165.

Vilar M, Murillo-Carretero M, Mira H, Magnusson K, Besset V, Ibáñez CF. Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J (2006) 25:1219-1230.

Volakakis N, Malewicz M, Kadkhodai B, Perlmann T, Benoit G. Characterization of the Nurr1 ligand-binding domain co-activator interaction surface. J Mol Endocrinol (2006) 37:317-326.

Williams C, Wirta V, Meletis K, Wikström L, Carlsson L, Frisén J, Lundeberg J. Catalog of gene expression in adult neural stem cells and their in vivo microenvironment. Exp Cell Res (2006) 312:1798-1812.

Zhang S, Malmersjö S, Li J, Ando H, Aizman O, Uhlén P, Mikoshiba K, Aperia A. Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer. J Biol Chem (2006) 281:21954-21962.

REVIEW ARTICLES AND BOOK CHAPTERS

Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. International Union of Pharmacology. LXVI. Orphan Nuclear Receptors. Pharmacol Rev (2006) 58:798-836.

Brodin L, Shupliakov O. Giant reticulospinal synapse in lamprey: molecular links between active and
periactive zones. Cell Tissue Res (2006) 326:301-310.

Castelo-Branco G, Arenas E. Function of Wnts in dopaminergic neuron development. Neurodegener Dis (2006) 3:5-11.

Sahlgren C, Lendahl U. Notch signaling and its integration with other signaling mechanisms. Regen Med (2006) 1:195-205.

2005 (CEDB)

ORIGINAL ARTICLES

Abrescia C, Sjöstrand D, Kjaer S, Ibáñez CF. Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells. FEBS Lett (2005) 579:3789-3796.

Aifa S, Aydin J, Nordvall G, Lundström I, Svensson SPS, Hermanson O. A basic peptide within the juxtamembrane region is required for EGF receptor dimerization. Exp Cell Res (2005) 302:108-114.

Berghuis P, Dobszay MB, Wang X, Spano S, Ledda F, Sousa KM, Schulte G, Ernfors P, Mackie K, Paratcha G, Hurd YL, Harkany T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A (2005) 102:19115-19120.

Bergman P, Termen S, Johansson L, Nyström L, Arenas E, Jonsson AB, Hökfelt T, Gudmundsson GH, Agerberth B. The antimicrobial peptide rCRAMP is present in the central nervous system of the rat. J Neurochem (2005) 93:1132-1140.

Brunkhorst A, Karlén M, Shi J, Mikolajczyk M, Nelson MA, Metsis M, Hermanson O. A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation. Mol Cell Neurosci (2005) 29:250-258.

Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M. Hypoxia requires Notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 9:617-628.

Hansson EM, Strömberg K, Bergstedt S, Yu G, Näslund J, Lundkvist J, Lendahl U. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch. J Neurochem (2005) 92:1010-1020.

Hassani H, Lucas G, Rozell B, Ernfors P. Attenuation of acute experimental colitis by preventing NPY Y1 receptor signaling. Am J Physiol (2005) 288:G550-556.

Heglind M, Cederberg A, Aquino J, Lucas G, Ernfors P, Enerbäck S. Lack of the central nervous system- and neural crest-expressed forkhead gene Foxs1 affects motor function and body weight. Mol Cell Biol (2005) 25:5616-5625.

Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M. NKX6 transcription factor activity is required for (alpha)- and (beta)-cell development in the pancreas. Development (2005) 132:3139-3149.

Hjerling-Leffler J, Marmigère F, Heglind M, Cederberg A, Koltzenburg M, Enerbäck S, Ernfors P. The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development (2005) 132:2623-2632.

Hofstetter CP, Holmström NA, Lilja JA, Schweinhardt P, Hao J, Spenger C, Wiesenfeld-Hallin Z, Kurpad SN, Frisén J, Olson L. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci (2005) 8:346-353.

Holmberg J, Armulik A, Senti KA, Edoff K, Spalding K, Momma S, Cassidy R, Flanagan JG, Frisén J. Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev (2005) 19:462-471.

Holmberg K, Kuteeva E, Brumovsky P, Kahl U, Karlström H, Lucas GA, Rodriguez J, Westerblad H, Hilke S, Theodorsson E, Berge OG, Lendahl U, Bartfai T, Hökfelt T. Generation and phenotypic characterization of a galanin overexpressing mouse. Neuroscience (2005) 133:59-77.

Hu Z, Wei D, Johansson CB, Holmström N, Duan M, Frisén J, Ulfendahl M. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Exp Cell Res (2005) 302:40-47.

Kobayashi M, Hjerling-Leffler J, Ernfors P. Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc. Cell Tissue Res (2006) 323:81-90.

Laudon H, Hansson EM, Melén K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Näslund J. A nine-transmembrane domain topology for presenilin 1. J Biol Chem (2005) 280:35352-35360.

Lengqvist J, Mata de Urquiza A, Perlmann T, Sjövall J, Griffiths WJ. Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. J Mass Spectrom (2005) 40:1448-1461.

Lengqvist J, Alvelius G, Jörnvall H, Sjövall J, Perlmann T, Griffiths WJ. Electrospray mass spectrometry for the direct accurate mass measurement of ligands in complex with the retinoid X receptor alpha ligand binding domain. J Am Soc Mass Spectrom (2005) 16:1631-1640.

Lieberam I, Agalliu D, Nagasawa T, Ericson J, Jessell TM. A cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron (2005) 47:667-679.

Lundkvist J, Zhu S, Hansson EM, Schweinhardt P, Miao Q, Beatus P, Dannaeus K, Karlström H, Johansson CB, Viitanen M, Rozell B, Spenger C, Mohammed A, Kalimo H, Lendahl U. Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype. Genesis (2005) 41:13-22.

May SR, Ashique AM, Karlén M, Wang B, Shen Y, Zarbalis K, Reiter J, Ericson J, Peterson AS. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 287:378-389.

Nosrat IV, Agerman K, Marinescu A, Ernfors P, Nosrat CA. Lingual deficits in neurotrophin double knockout mice. J Neurocytol (2004) 33:607-615.

Nyman U, Sobczak-Pluta A, Vlachos P, Perlmann T, Zhivotovsky B, Joseph B. Full-length p73alpha represses drug-induced apoptosis in small cell lung carcinoma cells. J Biol Chem (2005) 280:34159-34169.

Owe-Larsson B, Chaves-Olarte E, Chauhan A, Kjaerulff O, Brask J, Thelestam M, Brodin L, Löw P. Inhibition of hippocampal synaptic transmission by impairment of Ral function. Neuroreport (2005) 16:1805-1808.

Parish CL, Parisi S, Persico MG, Arenas E, Minchiotti G. Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease. Stem Cells (2005) 23:471-476.

Pineda JR, Canals JM, Bosch M, Adell A, Mengod G, Artigas F, Ernfors P, Alberch J. Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease. J Neurochem (2005) 93:1057-1068.

Pozas E, Ibáñez CF. GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron (2005) 45:701-713.

Sairanen M, Lucas G, Ernfors P, Castren M, Castren E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci (2005) 25:1089-1094.

Sandberg M, Kallström M, Muhr J. Sox21 promotes the progression of vertebrate neurogenesis. Nat Neurosci (2005) 8:995-1001.

Schulte G, Bryja V, Rawal N, Castelo-Branco G, Sousa KM, Arenas E. Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. J Neurochem (2005) 92:1550-1553.

Schwartz CM, Spivak CE, Baker SC, McDaniel TK, Loring JF, Nguyen C, Chrest FJ, Wersto R, Arenas E, Zeng X, Freed WJ, Rao MS. NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells. Stem Cells Dev (2005) 14:517-534.

Scott RP, Eketjäll S, Aineskog H, Ibáñez CF. Distinct turnover of alternatively-spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase. J Biol Chem (2005) 280:13442-13449.

Shariatmadari M, Peyronnet J, Papachristou P, Horn Z, Sousa KM, Arenas E, Ringstedt T. Increased Wnt levels in the neural tube impair the function of adherens junctions during neurulation. Mol Cell Neurosci (2005) 30:437-451.

Sievertzon M, Wirta V, Mercer A, Meletis K, Erlandsson R, Wikström L, Frisén J, Lundeberg J. Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method. BMC Neurosci (2005) 6:28.

Sievertzon M, Wirta V, Mercer A, Frisén J, Lundeberg J. Epidermal growth factor (EGF) withdrawal masks gene expression differences in the study of pituitary adenylate cyclase-activating polypeptide (PACAP) activation of primary neural stem cell proliferation. BMC Neurosci (2005) 6:55.

Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Burger A, Ericson J, Kispert A. Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development (2005) 132:2697-2707.

Spalding KL, Bhardwaj RD, Buchholz BA, Druid H, Frisén J. Retrospective birth dating of cells in humans. Cell (2005) 122:133-143.

Spalding KL, Buchholz BA, Bergman LE, Druid H, Frisén J. Forensics: age written in teeth by nuclear tests. Nature (2005) 437:333-334.

Stenqvist A, Agerman K, Marmigère F, Minichiello L, Ernfors P. Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo. EMBO Rep (2005) 6:973-978.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity. J Neurochem (2005) 95:880-890.

Vallstedt A, Klos JM, Ericson J. Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron (2005) 45:55-67.

Woldbye DP, Nanobashvili A, Sørensen AT, Husum H, Bolwig TG, Sørensen G, Ernfors P, Kokaia M. Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors. Neurobiol Dis (2005) 20:760-772.

REVIEW ARTICLES AND BOOK CHAPTERS

Arenas E. Engineering a dopaminergic phenotype in stem/precursor cells: Role of Nurr1, glia-derived signals, and Wnts. Ann N Y Acad Sci (2005) 1049:51-66.

Falk A, Frisén J. New neurons in old brains. Ann Med (2005) 37:480-486.

Mikkers H, Frisén J. Deconstructing stemness. EMBO J (2005) 24:2715-2719.

2004 (CEDB)

ORIGINAL ARTICLES

Bergman A, Hansson E, Pursglove SE, Farmery MR, Lannfelt L, Lendahl U, Lundkvist J, Näslund J. Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin. J Biol Chem (2004) 279:16744-16753.

Berghuis P, Dobszay MB, Sousa KM, Schulte G, Mager PP, Hartig W, Gorcs TJ, Zilberter Y, Ernfors P, Harkany T. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons. Eur J Neurosci (2004) 20:1290-1306.

Brunkhorst A, Neuman T, Hall A, Arenas E, Bartfai T, Hermanson O, Metsis M. Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity. Biochem Biophys Res Commun (2004) 325:574-579.

Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martin-Ibanez R, Munoz MT, Mengod G, Ernfors P, Alberch J. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. J Neurosci (2004) 24:7727-7739.

Castelo-Branco G, Rawal N, Arenas E. GSK-3ß inhibition/ß-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. J Cell Sci (2004) 117:5731-5737.

Codina A, Benoit G, Gooch JT, Neuhaus D, Perlmann T, Schwabe JW. Identification of a novel co regulator interaction surface on the ligand-binding domain of Nurr1 using NMR footprinting. J Biol Chem (2004) 279:53338-53345.

Coulpier M, Ibáñez CF. Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Mol Cell Neurosci (2004) 27:132-139.

Eketjäll S, Jörnvall H, Lönnerberg P, Kobayashi S, Ibáñez CF. Recent evolutionary origin within the primate lineage of two pseudogenes with similarity to members of the transforming growth factor-beta superfamily. Cell Mol Life Sci (2004) 61:488-496.

Enlund F, Behboudi A, Andren Y, Öberg C, Lendahl U, Mark J, Stenman G. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res (2004) 292:21-28.

Evergren E, Marcucci M, Tomilin N, Löw P, Slepnev V, Andersson F, Gad H, Brodin L, De Camilli P, Shupliakov O. Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse. Traffic (2004) 5:514-528.

Evergren E, Tomilin N, Vasylieva E, Sergeeva V, Bloom O, Gad H, Capani F, Shupliakov O. A pre-embedding immunogold approach for detection of synaptic endocytic proteins in situ. J Neurosci Methods (2004) 135:169-174.

Fetissov SO, Byrne LC, Hassani H, Ernfors P, Hökfelt T. Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. J Comp Neurol (2004) 470:256-265.

Grothe C, Timmer M, Scholz T, Winkler C, Nikkhah G, Claus P, Itoh N, Arenas E. Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons. Neurobiol Dis (2004) 17:163-170.

Harkany T, Andäng M, Kingma HJ, Gorcs TJ, Holmgren CD, Zilberter Y, Ernfors P. Region-specific generation of functional neurons from naive embryonic stem cells in adult brain. J Neurochem (2004) 88:1229-1239.

Harkany T, Holmgren C, Hartig W, Qureshi T, Chaudhry FA, Storm-Mathisen J, Dobszay MB, Berghuis P, Schulte G, Sousa KM, Fremeau RT Jr, Edwards RH, Mackie K, Ernfors P, Zilberter Y. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. J Neurosci (2004) 24:4978-4988.

Jiang, C.H., Hermanson O. Cooling of the urinary bladder activates neurons in the dorsal horn of the spinal cord. Neuroreport (2004) 15:351-355.

Jörnvall H, Reissmann E, Andersson O, Mehrkash M, Ibáñez CF. ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol (2004) 24:9383-9389.

Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. J Biol Chem (2004) 279:23925-23932.

Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. J Neurochem (2004) 89:44-53.

Lengqvist J, Mata De Urquiza A, Bergman AC, Wilson TM, Sjövall J, Perlmann T, Griffiths WJ. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand binding domain. Mol Cell Proteomics (2004) 692-703.

Mellodew K, Suhr R, Uwanogho DA, Reuter I, Lendahl U, Hodges H, Price J. Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling. Dev Brain Res (2004) 151:13-23.

Mercer A, Rönnholm H, Holmberg J, Lundh H, Heidrich J, Zachrisson O, Ossoinak A, Frisén J, Patrone C. PACAP promotes neural stem cell proliferation in adult mouse brain. J Neurosci Res (2004) 76:205-215.

Metsis A, Andersson U, Bauren G, Ernfors P, Lonnerberg P, Montelius A, Oldin M, Pihlak A, Linnarsson S. Whole-genome expression profiling through fragment display and combinatorial gene identification. Nucleic Acids Res (2004) 32:e127.

Nsegbe E, Wallén-Mackenzie Å, Dauger S, Roux JC, Shvarev Y, Lagercrantz H, Perlmann T, Herlenius E. Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice. J Physiol (2004) 556:43-59.

Nordzell M, Aarnisalo P, Benoit G, Castro DS, Perlmann T. Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1. Biochem Biophys Res Commun (2004) 313:205-211.

Samad OA, Geisen MJ, Caronia G, Varlet I, Zappavigna V, Ericson J, Goridis C, Rijli FM. Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins. Development (2004) 131:4071-4083.

Sandelin A, Bailey P, Bruce S, Engstrom PG, Klos JM, Wasserman WW, Ericson J, Lenhard B. Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes. BMC Genomics (2004) 5:99.

Sieber BA, Kuzmin A, Canals JM, Danielsson A, Paratcha G, Arenas E, Alberch J, Ögren SO, Ibáñez CF. Disruption of EphA/ephrin-A signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Mol Cell Neurosci (2004) 26:418-428.

Thiele TE, Naveilhan P, Ernfors P. Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice. Peptides (2004) 25:975-983.

REVIEW ARTICLES AND BOOK CHAPTERS

Benoit G, Malewicz M, Perlmann T. Digging deep into the pockets of orphan nuclear receptors: insights from structural studies. Trends Cell Biol (2004) 14:369-376.

Berghuis P, Dobszay MB, Ibanez RM, Ernfors P, Harkany T. Turning the heterogeneous into homogeneous: studies on selectively isolated GABAergic interneuron subsets. Int J Dev Neurosci (2004) 22:533-543.

Hansson EM, Lendahl U, Chapman G. Notch signaling in development and disease. Semin Cancer Biol (2004) 14:320-328.

Ibáñez CF. Lipid rafts as organizing platforms for cell chemotaxis and axon guidance. Neuron. (2004) 42:3-5.

Imokawa Y, Simon A, Brockes JP. A critical role for thrombin in vertebrate lens regeneration. Philos Trans R Soc Lond B Biol Sci (2004) 359: 765-776.

Perlmann T, Wallén-Mackenzie Å. Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells. Cell Tissue Res (2004) 318:45-52.

Szymkiewicz I, Shupliakov O, Dikic I. Cargo- and compartment-selective endocytic scaffold proteins. Biochem J (2004) 383:1-11.

COMMENTARIES AND LETTERS

Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Muller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W. The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 36:925-927.

Ibáñez CF. Framework reveals lack of basic-research funds. Nature (2004) 427:485.

2003 (CEDB)

ORIGINAL ARTICLES

Agerman K, Ernfors P. Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo. Neuroreport (2003) 14:2183-2187.

Agerman K, Hjerling-Leffler J, Blanchard MP, Scarfone E, Canlon B, Nosrat C, Ernfors P. BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development. Development (2003) 130:1479-1491.

Aguado F, Carmona MA, Pozas E, Aguilo A, Martinez-Guijarro FJ, Alcantara S, Borrell V, Yuste R, Ibáñez CF, Soriano E. BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2. Development (2003) 130:1267-1280.

Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, Pascucci M, Checquolo S, Gradini R, Lendahl U, Frati L, Gulino A, Di Mario U, Screpanti I. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol (2003) 171:4504-4511.

Backman C, You ZB, Perlmann T, Hoffer BJ. Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine. Behav Brain Res (2003) 143:95-100.

Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, Ibáñez CF. Cross-talk between the Notch and TGF-{beta} signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 163:723-728.

Bloom O, Evergren E, Tomilin N, Kjaerulff O, Löw P, Brodin L, Pieribone VA, Greengard P, Shupliakov O. Colocalization of synapsin and actin during synaptic vesicle recycling. J Cell Biol (2003) 161:737-747.

Bylund M, Andersson E, Novitch BG, Muhr J. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci (2003) 6:1162-1168.

Castelo-Branco G, Wagner J, Rodriguez FJ, Kele J, Sousa K, Rawal N, Pasolli HA, Fuchs E, Kitajewski J, Arenas E. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 100:12747-12752.

Cutforth T, Moring L, Mendelsohn M, Nemes A, Shah NM, Kim MM, Frisén J, Axel R. Axonal ephrin-as and odorant receptors. Coordinate determination of the olfactory sensory map. Cell (2003) 114:311-322.

Dahlqvist C, Blokzijl A, Chapman G, Falk A, Dannaeus K, Ibánñez CF, Lendahl U. Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (2003) 130:6089-6099.

Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, Deneris E, Johnson RL, Chen ZF. Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci (2003) 6:933-938.

Dufour A, Seibt J, Passante L, Depaepe V, Ciossek T, Frisén J, Kullander K, Flanagan JG, Polleux F, Vanderhaeghen P. Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph Genes. Neuron (2003) 39:453-465.

Fetissov SO, Xu ZQ, Byrne LC, Hassani H, Ernfors P, Hökfelt T. Neuropeptide Y targets in the hypothalamus: nitric oxide synthesizing neurones express y1 receptor. J Neuroendocrinol (2003) 15:754-7560.

Hall AC, Mira H, Wagner J, Arenas E. Region-specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons. Glia (2003) 43:47-51.

Harkany T, Hartig W, Berghuis P, Dobszay MB, Zilberter Y, Edwards RH, Mackie K, Ernfors P. Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons. Eur J Neurosci (2003) 18:1979-1992.

Hermanson E, Joseph B, Castro D, Lindqvist E, Aarnisalo P, Wallen A, Benoit G, Hengerer B, Olson L, Perlmann T. Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Exp Cell Res (2003) 288:324-334.

Holm PC, Rodriguez FJ, Kresse A, Canals JM, Silos-Santiago I, Arenas E. Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development (2003) 130:3535-3545.

Joseph B, Wallén-Mackenzie Å, Benoit G, Murata T, Joodmardi E, Okret S, Perlmann T. p57Kip2 cooperates with Nurr1 in developing dopamine cells. Proc Natl Acad Sci U S A (2003) 100(26):15619-15624.

Kjaer S, Ibáñez CF. Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET. Hum Mol Genet (2003) 12:2133-2144.

Kjaer S, Ibáñez CF. Identification of a surface for binding to the GDNF/GFRalpha 1 complex in the first cadherin-like domain of RET. J Biol Chem (2003) 278:47898-47904.

Krebs LT, Xue Y, Norton CR, Sundberg JP, Beatus P, Lendahl U, Joutel A, Gridley T. Characterization of Notch3-deficient mice: Normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 37:139-143.

Lillesaar C, Arenas E, Hildebrand C, Fried K. Responses of rat trigeminal neurones to dental pulp cells or fibroblasts overexpressing neurotrophic factors in vitro. Neuroscience (2003) 119:443-451.

Lucas G, Hendolin P, Harkany T, Agerman K, Paratcha G, Holmgren C, Zilberter Y, Sairanen M, Minichiello L, Castren E, Ernfors P. Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia. Nat Neurosci (2003) 6:221-222.

Mikaels-Edman A, Baudet C, Ernfors P. Soluble and bound forms of GFRalpha1 elicit different GDNF-independent neurite growth responses in primary sensory neurons. Dev Dyn (2003) 227:27-34.

Mitsiadis TA, Angeli I, James C, Lendahl U, Sharpe PT. Role of Islet1 in the patterning of murine dentition. Development (2003) 130:4451-4460.

Mitsiadis TA, Romeas A, Lendahl U, Sharpe PT, Farges JC. Notch2 protein distribution in human teeth under normal and pathological conditions. Exp Cell Res (2003) 282:101-109.

Paratcha G, Ledda F, Ibáñez CF. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell (2003) 113:867-879.

Pattyn A, Vallstedt A, Dias JM, Samad OA, Krumlauf R, Rijli FM, Brunet JF, Ericson J. Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes Dev (2003) 17:729-737.

Pattyn A, Vallstedt A, Dias JM, Sander M, Ericson J. Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development (2003) 130:4149-4159.

Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castren E. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci (2003) 23:349-357.

Sockanathan S, Perlmann T, Jessell TM. Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern. Neuron (2003) 40:97-111.

Wallén-Mackenzie Å, De Urquiza AM, Petersson S, Rodriguez FJ, Friling S, Wagner J, Ordentlich P, Lengqvist J, Heyman RA, Arenas E, Perlmann T. Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells. Genes Dev (2003) 17:3036-3047.

Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature (2003) 423:555-560.

Werme M, Hermanson E, Carmine A, Buervenich S, Zetterström RH, Thoren P, Ögren SO, Olson L, Perlmann T, Brené S. Decreased ethanol preference and wheel running in Nurr1-deficient mice. Eur J Neurosci (2003) 17:2418-2424.

Zhao M, Momma S, Delfani K, Carlén M, Cassidy RM, Johansson CB, Brismar H, Shupliakov O, Frisén J, Janson AM. Evidence for neurogenesis in the adult mammalian substantia nigra. Proc Natl Acad Sci U S A (2003) 100:7925-7930.

REVIEW ARTICLES AND BOOK CHAPTERS

Ernfors P, Bramham CR. The coupling of a trkB tyrosine residue to LTP. Trends Neurosci (2003) 26:171-173.

Mata de Urquiza A, Perlmann T. In vivo and in vitro reporter systems for studying nuclear receptor and ligand activities. Methods Enzymol (2003) 364:463-475.

Meletis K, Frisén J. Blood on the tracks: a simple twist of fate? Trends Neurosci (2003) 26:292-296.

Rosenfeld M.G., Jepsen K., Hermanson O. and Glass C.K. Mechanisms of Regulated Gene Transcription. In Epstein C.J., Erickson R.P., Wynshaw-Boris A. (eds) Inborn errors of development - The molecular basis of clinical disorders of morphogenesis. (2003) Oxford Monographs on Medical Genetics. Oxford University Press, 1082 pp.

Wallén A, Perlmann T. Transcriptional control of dopamine neuron development. Ann N Y Acad Sci (2003) 991:48-60.