Per Uhlén

Group members:
Per Uhlén, group leader
Simone Codeluppi, postdoc
Ivar Dehnisch, student
Nicolas Fritz, postdoc
Cristian Ibarra, postdoc
Marie Karlsson, PhD stud
Erik Nilsson, PhD stud
Katsutoshi Nakahata, postdoc
Paola Rebellato, PhD stud
Johnny Söderlund, labtech
Songbai Zhang, postdoc

PER UHLÉN
Department of Medical Biochemistry and Biophysics (MBB)
Per.Uhlen@ki.se

Our research group is studying developmental and cancer related processes in various types of cells. The biological platforms that we are applying are tissue slices, primary cell cultures, cell lines and stem cells. To study the processes of cell division, cell differentiation, and neural migration/networking we are applying state-of-the-art imaging techniques and modern genetic tools, such as transgenic animals. Our focus is to shed light on the intracellular cell signaling mechanisms that regulate these vital processes for development and disease. We are particularly interested in calcium signaling and how cells are modulating and decoding the frequency/amplitude of intracellular calcium oscillations.

5 SELECTED PUBLICATIONS:

Desfrere L., Karlsson M., Hiyoshi H., Malmersjö S., Nanou E., Estrada M., Miyakawa A., Lagercrantz H., El Manira A., Lal M., and Uhlén P. (2009) Na,K-ATPase signal transduction triggers CREB activation and dendritic growth. Proc. Natl. Acad. Sci. U.S.A. 106:2212-2217.

Edman L.C., Mira H., Erices A,. Malmersjö S., Andersson E., Uhlén P., and Arenas E. (2008) Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. Stem Cells 26:1891-1900.

Uhlén P., Burch P., Ivins Zito C., Estrada M., Ehrlich B.E., and Bennett A.M. (2006) Gain-of-function/Noonan Syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc. Natl. Acad. Sci. U.S.A. 103, 2160-2165.

Uhlén P. (2004) Spectral Analysis of Calcium Oscillations. Science STKE 258, pl15.

Uhlén P., Laestadius Å., Jahnukainen T., Söderblom T., Bäckhed F., Celsi G., Brismar H., Normark S., Aperia A., and Richter-Dahlfors A. (2000) Alpha-haemolysin of uropathogenic E.coli induces Ca2+ oscillations in renal epithelial cells. Nature 405, 694-697.

LINKS:

For more information, please visit here or our lab website.