Jan Stenman

Group members:
Jan Stenman, group leader
Belma Hot, PhD stud
Mike Hupe, postdoc
Julianna Kele Olovsson, postdoc
Minerva Li, PhD stud
Chika Yokota, Scientist

JAN STENMAN
Ludwig Institute for Cancer Research
Jan.Stenman@licr.ki.se

We are interested in the molecular regulation and biological functions of the Wnt signaling pathway.

Alterations of Wnts, and components of the Wnt signaling pathways are key to many diseases, such as malignances. We want to understand how active Wnt proteins are produced and secreted, how Wnt protein and pathway activity is regulated, and the function of Wnt proteins in specific biological contexts. We are currently addressing these questions by:

1. performing large-scale screens to identify novel regulators of Wnt protein and pathway activity using both cell based assays and the Xenopus model system.
2. studying the role(s) of canonical Wnt signal transduction in the central nervous system vasculature during development and disease.

5 SELECTED PUBLICATIONS:

Stenman J.M., Rajagopal J., Carroll T.J., and McMahon A.P. (2008) Canonical Wnt signaling regulate organ-specific assembly and differentiation of CNS vasculature. Science 322:1247-1250.

Gray P.A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D.I., Tsung E.F., Cai Z., Alberta J.A., Cheng L.P,. Liu Y., Stenman J.M., Valerius M.T., Billings N., Kim H.A., Greenberg M.E., McMahon A.P., Rowitch D.H., Stiles C.D., and Ma Q. (2004) Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306:2255-2257.

Stenman J.M., Wang B., and Campbell, K. (2003) Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. J. Neurosci. 23:10568-10576.

Stenman J., Yu R.T., Evans R.M., and Campbell K. (2003) Tlx and Pax6 co-operate genetically to establish dorsal-ventral identity in the embryonic mouse telencephalon. Development 130:1113-1122.

Stenman J., Toresson H., and Campbell K. (2003) Identification of two distinct progenitor populations in the lateral ganglionic eminence: Implications for striatal and olfactory bulb neurogenesis. J. Neurosci. 23:167-174.

LINKS:

For more information, please visit our website at LICR.