Jonas Muhr

Group members:
Jonas Muhr, group leader
Maria Bergsland, postdoc
Daniel Hagey, PhD stud
Alexandra Karlén, postdoc
Susanne Klum, PhD stud
Idha Kurtsdotter, PhD stud
Soheilla Rezaian, senior technician
Cecile Zaouter, PhD stud

JONAS MUHR
Ludwig Institute for Cancer Research
Jonas.Muhr@licr.ki.se

The main focus of the lab is to elucidate the molecular processes that regulate the generation of neurons from stem cells in the developing CNS.

We are especially interested in the interplay between the molecular cues that promote the differentiation of neurons and those that act to maintain neural cells in a self-renewing progenitor state. To approach these issues, we are utilizing transgenic chick embryos as an in vivo model in combination with in vitro primary neural cell culture systems.

5 SELECTED PUBLICATIONS:

Bergsland M., Werme M., Malewicz M., Perlmann T., and Muhr J. (2006) The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes Dev. 20:3475-3486.

Sandberg M., Källström M., and Muhr J. (2005) Sox21 promotes the progression of vertebrate neurogenesis. Nat. Neurosci. 8, 995-1001.

Bylund M., Andersson E., Novitch B.G., and Muhr J. (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat. Neurosci. 6, 1162-1168.

Vallstedt A., Muhr J., Pattyn A., Pierani A., Mendelsohn M., Sander M., Jessell T.M., and Ericson J. (2001) Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron 31, 743-755.

Muhr J, Andersson E, Persson M, Jessell TM, Ericson J. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell. 2001 Mar 23;104(6):861-73.

LINKS:

For more information, please visit our lab website.