Urban Lendahl

Group members:
Urban Lendahl, group leader
Emma Andersson, postdoc
Susanne Bergstedt, lab engineer
Indira Chivkulla, PhD stud
Tanya Henshall, postdoc
Shaobo Jin, postdoc
Sebastian Landor, PhD stud
Heather Main, PhD stud
Anders Mutvei, PhD stud

URBAN LENDAHL
Department of Cell and Molecular Biology (CMB)
Urban.Lendahl@ki.se

Our laboratory is interested in the Notch signaling pathway and its role in cellular differentiation in health and disease.

We focus on the molecular mechanisms underpinning Notch signaling, both with regard to the core signaling pathway and the roles of various Notch accessory proteins that modulate Notch signaling. An important focus of the laboratory is to understand how Notch signaling is integrated with other major signaling pathways, and we work on cross-talk between Notch and BMP/TGF-beta, Notch and Wnt, and Notch and cellular hypoxia. In the latter project, we address the consequences of the cross-talk both in stem cells and tumor cells. Finally, we explore how Notch controls differentiation in various stem/progenitor cell types, with a particular focus on ES cells, myogenic progenitors and vascular smooth muscle cells.

5 SELECTED PUBLICATIONS:

Landor S., Mutvei A., Mamaeva V., Jin S., Busk M., Borra R., Lendahl U., and Sahlgren, C. (2011) Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms. Proc. Natl. Acad. Sci. USA, in press.

Andersson E.R., Sandberg, R., and Lendahl, U. (2011) Notch signaling: simplicity in design, versatility in function. Development 138:3593-3612.

Sahlgren C., Gustafsson M.V., Jin S., Poellinger L., and Lendahl U. (2008) Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc. Natl. Acad. Sci. USA 105:6392-6397.

Jin S., Hansson E.M., Tikka S., Lanner F., Sahlgren C., Farnebo F., Baumann M., Kalimo H., and Lendahl U. (2008) Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. Circ. Res. 102:1483-1491.

Gustafsson M.V., Zheng X., Pereira T., Gradin K., Jin S., Lundkvist J., Ruas J.L., Poellinger L., Lendahl U., and Bondesson M. (2005) Hypoxia requires Notch signaling to maintain the undifferentiated cell state. Dev. Cell 9, 617-628.

LINKS:

For more information, please visit our lab website.