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- Translational Research Center
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Group
members:
Urban
Lendahl, group leader
Susanne Bergstedt, lab engineer
Debashis Das, postdoc
Shaobo Jin, postdoc
Heather Main, PhD stud
Anders Mutvei, undergrad
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URBAN
LENDAHL
Department of Cell and
Molecular Biology (CMB)
Urban.Lendahl@ki.se
Our
laboratory is interested in the Notch signaling pathway and its role
in cellular differentiation in health and disease.
We
focus on the molecular mechanisms underpinning Notch signaling, both
with regard to the core signaling pathway and the roles of various Notch
accessory proteins that modulate Notch signaling. An important focus
of the laboratory is to understand how Notch signaling is integrated
with other major signaling pathways, and we work on cross-talk between
Notch and BMP/TGF-beta, Notch and Wnt, and Notch and cellular hypoxia.
In the latter project, we address the consequences of the cross-talk
both in stem cells and tumor cells. Finally, we explore how Notch controls
differentiation in various stem/progenitor cell types, with a particular
focus on ES cells, myogenic progenitors and vascular smooth muscle cells.
5
SELECTED
PUBLICATIONS:
Sahlgren
C., Gustafsson M.V., Jin S., Poellinger L., and Lendahl U. (2008) Notch
signaling mediates hypoxia-induced tumor cell migration and invasion.
Proc. Natl. Acad. Sci. USA 105:6392-6397.
Jin
S., Hansson E.M., Tikka S., Lanner F., Sahlgren C., Farnebo F., Baumann
M., Kalimo H., and Lendahl U. (2008) Notch signaling regulates platelet-derived
growth factor receptor-beta expression in vascular smooth muscle cells.
Circ. Res. 102:1483-1491.
Chapman
G., Liu L., Sahlgren C., Dahlqvist C., and Lendahl U. (2006) High levels
of Notch signaling down-regulate Numb and Numblike. J. Cell Biol.
175, 535-540.
Gustafsson
M.V., Zheng X., Pereira T., Gradin K., Jin S., Lundkvist J., Ruas J.L.,
Poellinger L., Lendahl U., and Bondesson M. (2005) Hypoxia requires
Notch signaling to maintain the undifferentiated cell state. Dev.
Cell 9, 617-628.
Dahlqvist
C., Blokzijl A., Chapman G., Falk A., Dannaeus K., Ibáñez
C.F., and Lendahl U. (2003) Functional Notch signaling is required for
BMP4-induced inhibition of myogenic differentiation. Development
130, 6089-6099.
LINKS:
For
more information, please visit our lab
website.
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