Carlos Ibáñez

Group members:
Carlos Ibáñez, group leader
Ishrath Ansurudeen, postdoc
Berit Engst, lab technician
Christina Göngrich, postdoc
Carolyn Marks, PhD stud
Annalena Moliner, lab engineer
Maurice Perrinjaquet, PhD stud
Anastasia Simi, postdoc
Annalisa Vicario, postdoc
Haiya Wu, postdoc
Sabrina Zechel, postdoc

CARLOS F. IBÁÑEZ
Department of Neuroscience
Carlos.Ibanez@ki.se

Our group studies growth factor receptor signaling and biology in nervous system development and metabolic regulation. With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation. Currently, our studies center on three different ligand/receptor systems:

• p75 neurotrophin receptor (p75NTR) and neurotrophin family ligands
• GFRa1, Ret and NCAM receptors and GDNF family ligands
• TGF-beta superfamily receptors ALK7 and ALK4 and their ligands Activins and GDFs

Using these signaling systems as entry points, our goal is to discover novel, general biological principles of broad importance for nervous system development and metabolic functions.

5 SELECTED PUBLICATIONS:

Vilar M., Charalampopoulos I., Kenchappa R.S., Simi A., Karaca E., Reversi, A., Choi S., Bothwell M., Mingarro I., Friedman W.J., Schiavo G., Bastiaens P.I.H., Verveer P.J., Carter B.D., and Ibáñez C.F. (2009) Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron 62, 72-83.

Bertolino P., Nilsson R., Reissmann E., Andersson O., Berggren P.-O., and Ibáñez C.F. (2008) Activin B receptor ALK7 is a negative regulator of pancreatic b-cell function. Proc. Natl. Acad. USA 105, 7246-7251.

Andersson O., Korach-Andre M., Reissmann E., Ibáñez C.F. (corresp. Author), and Bertolino P. (2008) Growth/Differentiation Factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc. Natl. Acad. USA 105, 7252-7256.

Ledda F., Paratcha G., Sandoval-Guzmán T., and Ibáñez C.F. (2007) GDNF and GFRa1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat. Neurosci. 10, 293-300.

Vilar M., Murillo-Carretero M., Mira H., Magnusson K., Besset V., and Ibáñez, C.F. (2006) Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J. 25, 1219-1230.

LINKS:

For more information, please visit our lab website.