Jonas Frisén

Group members:
Jonas Frisén, group leader
Kanar Alkass, PhD stud
Olaf Bergmann, postdoc
James Chell, postdoc
David Dias, PhD stud
Aurelie Ernst, postdoc
Christian Goeritz, postdoc
Hagen Huttner, postdoc
Aleksandra Jurek, postdoc
Helena Lönnqvist, lab manager
Jens Magnusson, PhD stud
Jeff Mold, postdoc
Marta Paterlini, senior scientist
Pedro Réu, PhD stud
Hanna Sabelström, PhD stud
Klas Strååt, postdoc
Marcelo Toro, FACS operator
Maggie Yeung, PhD stud
Sofia Zdunek, PhD stud

JONAS FRISÉN
Department of Cell and Molecular Biology (CMB)
Jonas.Frisen@ki.se

Stem cell biology and regenerative medicine.

Many cell types in the adult body are constantly replaced from stem cells. A precise regulation of this process is required for organ homeostasis and to avoid tissue atrophy or tumor development. We are interested in how cell production is regulated, and address this by studying the identity of stem and progenitor cells, their molecular regulation and the extent of cell replacement in different regions and situations. Most of our studies focus on the adult central nervous system and the generation of neurons in the adult brain, but we are also interested in embryonic stem cells, heart, intestine, skin and the hematopoietic system. To study cell turnover in humans, we have developed a method to retrospectively determine the age of cells by measuring the integration of 14C derived from nuclear bomb tests. This allows us to determine whether for example neurons are renewed in different regions of the adult human brain and whether this process is affected in certain pathologies.

5 SELECTED PUBLICATIONS:

Göritz C., Dias D., Tomilin N., Barbacid M., and Frisén, J. (2011) A pericyte origin of spinal cord scar tissue. Science 333, 238-242.

Genander M., Halford M.M., Xu N.-J., Eriksson M., Yu Z., Qiu Z., Martling A., Greicius G., Thakar S., Catchpole T. Chumley M.J., Zdunek S., Wang C., Holm T., Goff S.P., Pettersson S., Pestell R.G., Henkemeyer M., and Frisén, J. (2009) Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139, 679-692.

Bergmann O., Bhardwaj R.D., Bernard S., Zdunek S., Barnabé-Heider F., Walsh S., Zupicich J., Alkass K., Buchholtz B.A., Druid H., Jovinge S., and Frisén, J. (2009) Evidence for cardiomyocyte renewal in humans. Science 324, 98-102.

Holmberg J., Genander M., Halford M.M., Annerén C., Sondell M., Chumley M.J., Silvany R.E., Henkemeyer M., and Frisén, J. (2006) EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell 125, 1151-1163.

Spalding K., Bhardwaj R., Buchholz B., Druid H., and Frisén, J. (2005) Retrospective birth dating of cells in humans. Cell 122, 133-143.

LINKS:

For more information, please visit our lab websites Here or Here. You may also be interested in our human regenerative map, visit the website here.