Lennart Brodin

Group members:
Joel Jakobsson, postdoc

LENNART BRODIN
Department of Neuroscience
Lennart.Brodin@ki.se

Information processing in the brain depends on release of neurotransmitters from synaptic vesicles at nerve terminals. We study the molecular mechanisms that control synaptic vesicle cycling in the developing and adult nervous system, and the relationship between these mechanisms and neurodegenerative disease mechanisms. Current problems include how the direct and endosomal routes of synaptic vesicle recycling are regulated, and how amyloid precursor protein (APP) is processed into Abeta peptides in nerve terminals. Formation of toxic Abeta peptides at synapses has been linked with the level of synaptic vesicle cycling in nerve terminals, and it is thought to contribute to the synaptic pathology in Alzheimer's disease.

5 SELECTED PUBLICATIONS:

Brodin L, Gregory J,and Ackermann F. (2011) Soluble membrane trafficking proteins taking a break at silent synaptic vesicles. Proc. Natl. Acad. Sci. USA 108, 16869-16870.

Jakobsson J, Ackermann F, Andersson F, Larhammar D, Löw P, and Brodin L. (2011) Regulation of synaptic vesicle budding and dynamin function by an EHD ATPase. J. Neurosci. 31, 13972-13980.

Andersson F, Löw P, Brodin L. (2010) Selective perturbation of the BAR domain of endophilin impairs synaptic vesicle endocytosis. Synapse 64, 556-560.

Jakobsson, J., Gad, H., Andersson, F., Löw, P., Shupliakov, O., Brodin, L. (2008) Role of epsin in synaptic vesicle endocytosis. Proc. Natl. Acad. Sci. USA 10, 6445-6450.

Andersson, F., Jakobsson, J., Löw, P., Shupliakov, O., Brodin, L. (2008) Perturbation of syndapin/PACSIN impairs synaptic vesicle endocytosis evoked by intense stimulation. J. Neurosci. 28, 3925-3933.

LINKS:

For more information, please visit our lab website.